Mounjaro (tirzepatide) is a brand-name injection prescribed for blood sugar management in people with type 2 diabetes. Mounjaro isn’t known to cause headaches, but you may develop a headache if your blood sugar gets too low.

In Mounjaro’s clinical trials, headaches weren’t a reported side effect in people taking the drug. However, headaches can be a symptom of other side effects, such as hypoglycemia. With hypoglycemia, your blood sugar levels become too low, which can lead to various symptoms, including:
- headaches
- dizziness and lightheadedness
- sweating
- confusion
- blurry vision
- slurred speech
- feeling weak, shaky, or jittery
- rapid heart rate
- mood changes, such as anxiety and irritability
- hunger
Nausea may be a symptom of other side effects, such as dehydration. It could also be a side effect of Mounjaro itself. Nausea was commonly reported in clinical trials of people using Mounjaro.
To reduce the chances of getting headaches while using Mounjaro, you will want to manage side effects like hypoglycemia and dehydration that may cause them. Some ways you can manage those side effects include:
- drinking plenty of liquids so that you don’t become dehydrated
- eating meals regularly
- avoiding skipping meals
- monitoring your blood sugar levels consistently
Medical Perspective“Maintaining adequate hydration prevents headaches because it allows your body to stay balanced and provide blood flow to your brain. Your body and brain require adequate fluids to work properly.”
— Kiran Khanani, PharmD
Learn more about GLP-1 drugs and dehydration.
Quotes represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.
No, Mounjaro doesn’t help with migraines. Mounjaro is approved by the Food and Drug Administration (FDA) to manage blood sugar levels in people with type 2 diabetes. Doctors may also prescribe it off-label for weight loss. Off-label use is when a drug is prescribed for a condition other than what it was approved for. However, Mounjaro does not have FDA approval to help treat or prevent migraine.
Talk with your doctor if you’re experiencing migraine. They can look for potential causes and suggest treatments to help you manage them.
Mounjaro isn’t known to cause headaches. However, headaches may be a symptom of other side effects, such as hypoglycemia or dehydration. You may be able to decrease your chances of getting headaches by monitoring your blood sugar levels, eating meals regularly, and more.
If you’re experiencing headaches while using Ozempic, talk with your doctor. They can suggest ways to help you best manage this condition.



